A Review of Statin Intolerance: a Focus on Statin-Attributed Muscle Symptoms.

Carl E Orringer, Jelani K Grant, Lale Tokgozoglu

Journal: Current atherosclerosis reports 2022;24(11):839-847

PMID: 36001213

Abstract

PURPOSE OF REVIEW

To provide a systematic approach to management of the patient with statin-attributed muscle symptoms.

RECENT FINDINGS

We examined the prevalence of statin intolerance, the role of the nocebo effect, key findings in the patient's history and laboratory studies, the potential value of coronary calcium scoring, and the importance of shared decision-making in considering statin re-initiation. Most patients with statin-attributed muscle symptoms can be successfully treated with statins or a combination of statins and non-statins to achieve successful ASCVD risk reduction.

Address: Department of Medicine, Cardiovascular Division, University of Miami Miller School of Medicine, 1120 NW 14th Street, Suite 1111, Miami, FL, 33136, USA. [email protected].; Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Cardiology, Hacettepe University, Ankara, Turkey.

DOI: 10.1007/s11883-022-01059-x

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Full Text Sources:

https://dx.doi.org/10.1007/s11883-022-01059-x

MeSH Terms: Calcium, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Muscles, Nocebo Effect, Prevalence