Platelet lysate and tendon healing: comparative analysis of autologous frozen-thawed PRP and ketorolac tromethamine in the treatment of patients with rotator cuff tendinopathy.

Raha Markazi, Mohammad Sadegh Soltani-Zangbar, Majid Zamani, Shadi Eghbal-Fard, Roza Motavalli, Amin Kamrani, Sanam Dolati, Majid Ahmadi, Leili Aghebati-Maleki, Amir Mehdizadeh, Fariba Eslamian, Alireza Pishgahi, Mehdi Yousefi

Journal: Growth factors (Chur, Switzerland) 2022;40(5-6):163-174

PMID: 36026559

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Abstract

Platelet-rich blood derivatives are being nowadays increasingly used in the treatment of tendon-related pathologies as a rich source of growth factors. We sought to ascertain if local application of platelet lysate (PL) to augment rotator cuff repair ameliorates patient outcomes compared to ketorolac tromethamine treated group. A total of forty patients, with clinical diagnosis of Rotator Cuff Tendinopathy were randomized to receive sub acromial injections of PL every week for a total of 3 injections and two injection of ketorolac tromethamine once every two weeks. Subjective assessments included VAS, SPADI and shoulder range of motion were assessed at baseline and at 1 and 6 months after injection. Taking both control and PL groups, it was vividly seen that the outcomes were identical at the initial state, as well as the short-term one; whereas, when considering the 6-month period, there is a seemingly remarkable superiority in PL group in all parameters.

Address: Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Medical Laboratory Sciences, Faculty of Allied Medicine, Infectious Diseases Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

DOI: 10.1080/08977194.2022.2093198

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https://www.tandfonline.com/doi/10.1080/08977194.2...

MeSH Terms: Humans, Rotator Cuff, Ketorolac Tromethamine, Rotator Cuff Injuries, Platelet-Rich Plasma, Tendinopathy, Tendons, Treatment Outcome