Anticancer and Anti-Inflammatory Mechanisms of NOSH-Aspirin and Its Biological Effects.

Jun Zhou, Weihong Zeng, Ying Zeng, Yukun Li, Zheng Xiao, Juan Zou, Lijun Peng, Jiliang Xia, Xi Zeng

Journal: Computational and mathematical methods in medicine 2022;2022():4463294

PMID: 36035295

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Abstract

NOSH-Aspirin, which is generated from NO, HS, and aspirin, affects a variety of essential pathophysiological processes, including anti-inflammatory, analgesic, antipyretic, antiplatelet, and anticancer properties. Although many people acknowledge the biological significance of NOSH-Aspirin and its therapeutic effects, the mechanism of action of NOSH-Aspirin and its regulation of tissue levels remains obscure. This is in part due to its chemical and physical features, which make processing and analysis difficult. This review focuses on the biological effects of NOSH-Aspirin and provides a comprehensive analysis to elucidate the mechanism underlying its disease-protective benefits.

Address: Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.; School of Nursing, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.; Department of Spine Surgery, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China.

DOI: 10.1155/2022/4463294

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MeSH Terms: Anti-Inflammatory Agents, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Disulfides, Humans, Nitrates