Posttranslational control of lipogenesis in the tumor microenvironment.

Yahui Zhu, Xingrong Lin, Xiaojun Zhou, Edward V Prochownik, Fubing Wang, Youjun Li

Journal: Journal of hematology & oncology 2022;15(1):120

PMID: 36038892

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Abstract

Metabolic reprogramming of cancer cells within the tumor microenvironment typically occurs in response to increased nutritional, translation and proliferative demands. Altered lipid metabolism is a marker of tumor progression that is frequently observed in aggressive tumors with poor prognosis. Underlying these abnormal metabolic behaviors are posttranslational modifications (PTMs) of lipid metabolism-related enzymes and other factors that can impact their activity and/or subcellular localization. This review focuses on the roles of these PTMs and specifically on how they permit the re-wiring of cancer lipid metabolism, particularly within the context of the tumor microenvironment.

Address: Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430072, China.; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, 430071, China.; School of Medicine, Chongqing University, Chongqing, 400030, China.; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430072, China.; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, 430071, China.; Division of Hematology/Oncology, Children's Hospital of Pittsburgh of UPMC, The Department of Microbiology and Molecular Genetics, The Pittsburgh Liver Research Center and The Hillman Cancer Center of UPMC, The University of Pittsburgh Medical Center, Pittsburgh, PA, 15224, USA.; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430072, China. [email protected].; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430072, China. [email protected].; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, 430071, China. [email protected].

DOI: 10.1186/s13045-022-01340-1

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Full Text Sources:

Medical:

https://medlineplus.gov/cancer.html

Miscellaneous:

https://assays.cancer.gov/CPTAC-1532

MeSH Terms: Humans, Lipid Metabolism, Lipogenesis, Neoplasms, Protein Processing, Post-Translational, Tumor Microenvironment