The role and potential mechanism of O-Glycosylation in gastrointestinal tumors.

Feinan Zhou, Jia Ma, Yongfu Zhu, Tianming Wang, Yue Yang, Yehan Sun, Youmou Chen, Hang Song, Xingxing Huo, Jianye Zhang

Journal: Pharmacological research 2022;184():106420

PMID: 36049664

Full Text on Elsevier Science View on PubMed

Abstract

Glycosylation is a critical post-translational modification (PTM) that affects the function of proteins and regulates cell signaling, thereby regulating various biological processes. Protein oxygen-N-acetylglucosamine (O-GlcNAc) glycosylation modifications are glycochemical modifications that occur within cells in the signal transduction and are frequently found in the cytoplasm and nucleus. Due to the rapid and reversible addition and removal, O-GlcNAc modifications are able to reversibly compete with certain phosphorylation modifications, immediately regulate the activity of proteins, and participate in kinds of cellular metabolic and signal transduction pathways, playing a pivotal role in the regulation of tumors, diabetes, and other diseases. This article provided a brief overview of O-GlcNAc glycosylation modification, introduced its role in altering the progression and immune response regulation of gastrointestinal tumors, and discussed its potential use as a marker of tumor neogenesis.

Address: The department of Spleen and Stomach Diseases of Cadres Healthcare Centre, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui Province 230000, China. Electronic address: [email protected].; The First Department of Oncology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui Province 230000, China. Electronic address: [email protected].; The First Department of Oncology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui Province 230000, China. Electronic address: [email protected].; Laboratory of Infection and Immunity, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Anhui Province 230000, China. Electronic address: [email protected].; Laboratory of Infection and Immunity, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Anhui Province 230000, China. Electronic address: [email protected].; The First Department of Oncology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui Province 230000, China. Electronic address: [email protected].; The First Department of Oncology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui Province 230000, China. Electronic address: [email protected].; Department of Biochemistry and Molecular Biology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Anhui Province 230000, China. Electronic address: [email protected].; Experimental Center of Clinical Research, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui Province 230000, China. Electronic address: [email protected].; Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangdong Province 510799, China. Electronic address: [email protected].

DOI: 10.1016/j.phrs.2022.106420

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MeSH Terms: Acetylglucosamine, Gastrointestinal Neoplasms, Glycosylation, Humans, N-Acetylglucosaminyltransferases, Oxygen, Protein Processing, Post-Translational