Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.

Address: William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS trust, London, UK.; Amsterdam UMC, University of Amsterdam, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Cardiovascular Research Center, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Deptartment of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands.; Maastricht Center for Systems Biology MaCSBio, Maastricht University, Maastricht, The Netherlands.; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Eurac Research, Institute for Biomedicine affiliated with the University of Lübeck, Bolzano, Italy.; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, The Netherlands.; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.; Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.; Department of Epidemiology, Erasmus MC - University Medical Center, Rotterdam, The Netherlands.; DZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics; Department of Functional Genomics, University Medicine Greifswald, Greifswald, Germany.; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, USA.; Cardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, USA.; Department of Health Data Science, University of Liverpool, Liverpool, UK.; California Pacific Medical Center, Research Institute, San Francisco, CA, USA.; Department of Cardiology, University Hospital, LMU Munich, Munich, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Genetics Research Centre, St George's University of London, London, UK.; Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK.; Laboratory of Experimental Cardiology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.; National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Department of Data Science, University of Mississippi Medical Center, Jackson, USA.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; IBE, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics IMBEI, University Medical Center, Johannes Gutenberg University, Mainz, Germany.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Translational Gerontology Branch, National Institute on Aging, National Institute of Health, Baltimore, US.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, The Netherlands.; Cardiovascular Disease Initiative, Broad Institute, Cambridge, MA, USA.; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Genetics, Ecology and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte/Minas Gerais, Brazil.; Population Health Research Institute, McMaster University, Hamilton, Canada.; Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Quebec, Canada.; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.; Institute of Cardiovascular Sciences, University of College London, London, UK.; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.; Brighton and Sussex Medical School, Brighton, UK.; Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland.; Laboratory for Molecular Cardiology, The Heart Centre, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.; Usher Institute, University of Edinburgh, Nine, Edinburgh Bioquarter, 9 Little France Road, Edinburgh, UK.; Health Data Research UK, University of Edinburgh, Nine, Edinburgh Bioquarter, 9 Little France Road, Edinburgh, UK.; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.; Department of Medicine, University of Illinois at Chicago, Chicago, USA.; Cardiothoracovascular Department, ASUGI, University of Trieste, Trieste, Italy.; Department of Data and Data Support, Region Zealand, 4180, Sorø, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2100, Copenhagen, Denmark.; Department of Laboratory Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.; Cardiovascular Disease Initiative, Broad Institute, Cambridge, MA, USA.; Demoulas Center for Cardiac Arrhythmias and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; DZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany.; Department of Internal Medicine B - Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine; University Medicine Greifswald, Greifswald, Germany.; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; Eurac Research, Institute for Biomedicine affiliated with the University of Lübeck, Bolzano, Italy.; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, USA.; Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Pediatrics/Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Pediatrics/David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology/University of Washington, Seattle, WA, USA.; Cardiology Division and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, 02114, USA.; Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and University Hospital of Oulu, Oulu, Finland.; Department of Pediatrics, Tampere University Hospital, Tampere, Finland.; Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Tampere Centre for Skills Training and Simulation, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Center for Clinical and Translational Science, Ohio State Medical Center, Columbus, OH, USA.; Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, NL, The Netherlands.; Department of Genetics, Ecology and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte/Minas Gerais, Brazil.; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Deptartment of Medical Sciences, Uppsala University, Uppsala, Sweden.; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Global Cardiometabolic Health, Departments of Epidemiology, Medicine and Surgery, Brown University, Providence, USA.; Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK.; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technical University of Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research, partner site: Munich Heart Alliance, Munich, Germany.; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; DZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.; Cardiovascular Disease Initiative, Broad Institute, Cambridge, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.; Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Population Health Research Institute, McMaster University, Hamilton, Canada.; Genetics Research Centre, St George's University of London, London, UK.; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Eurac Research, Institute for Biomedicine affiliated with the University of Lübeck, Bolzano, Italy.; Department of Neurology, University of Lübeck, Lübeck, Germany.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Department of Epidemiology/University of Washington, Seattle, WA, USA.; Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA.; Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Brazil, Belo Horizonte, Minas Gerais, Brazil.; Cardiology Service and Telehealth Center, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, Belo Horizonte, Minas Gerais, Brazil.; Department of Biostatistics, University of Washington, Seattle, WA, USA.; Labormedizinisches zentrum Dr. Risch, Vaduz, Liechtenstein.; Faculty of Medical Sciences, Private University in the Principality of Liechtenstein, Triesen, Liechtenstein.; Center of Laboratory Medicine, University Institute of Clinical Chemistry, University of Bern, Inselspital, Bern, Switzerland.; Laboratory of Genetics and Genomics, National Institute on Aging, National Institute of Health, Baltimore, US.; Deptartment of Physiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Digital Health Center, Hasso Plattner Institute, University of Potsdam, Potsdam, Germany.; Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Greater Bay Area Institute of Precision Medicine Guangzhou, Fudan University, Nansha District, Guangzhou, China.; Department of Medicine, Division of Cardiovascular Medicine, Arrhythmia Section, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cardiology, University Hospital, LMU Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research, partner site: Munich Heart Alliance, Munich, Germany.; Epidemiological Cardiology Research Center EPICARE, Wake Forest School of Medicine, Winston Salem, USA.; Maastricht Center for Systems Biology MaCSBio, Maastricht University, Maastricht, The Netherlands.; Dept. of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, NL, The Netherlands.; Institute of Human Genetics, Genetic Epidemiology, University of Muenster, Muenster, Germany.; Laboratory of Cardiovascular Sciences, National Institute on Aging, National Institute of Health, Baltimore, US.; Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.; DZHK German Centre for Cardiovascular Research; partner site Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research, partner site: Munich Heart Alliance, Munich, Germany.; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Cardiovascular Disease Initiative, Broad Institute, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, USA.; Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, 27599, USA.; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, USA.; Department of Cardiology, Beth Israel Deaconess Medical Center, Boston, USA.; Departments of Medicine, Pediatrics and Population Health Science, University of Mississippi Medical Center, Jackson, USA.; Institute of Genetic and Biomedical Rsearch, Italian National Research Council, Monserrato, Italy.; Center for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA, USA.; Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.; Department of Medical Sciences, University of Trieste, Trieste, Italy.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Unit of Primary Health Care, Oulu University Hospital, Oulu, Finland.; Department of Epidemiology and Biostatistics, MRC PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands.; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Instituto René Rachou, fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil.; Department of Medicine, Duke University, Durham, NC, USA.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.; Department of Health Data Science, University of Liverpool, Liverpool, UK.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS trust, London, UK.; Institute of Cardiovascular Sciences, University of College London, London, UK.; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; DZHK (German Centre for Cardiovascular Research, partner site: Munich Heart Alliance, Munich, Germany.; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology/University of Washington, Seattle, WA, USA.; Health Systems and Population Health, University of Washington, Seattle, WA, USA.; Institute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Pediatrics/Harbor-UCLA Medical Center, Torrance, CA, USA.; Departments of Pediatrics and Human Genetics/David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, The Netherlands.; Department of Cardiology, Heart and Lung Division, University Medical Center Utrecht, Utrecht, The Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.; Cardiovascular Health Research Unit, Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK.; Genomics and Translational Biomedicine, College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. [email protected].; Cardiovascular Research Center, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. [email protected].; William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London, UK. [email protected].; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. [email protected].