Cellular reprogramming, chemoresistance, and dietary interventions in breast cancer.

Irislene Costa Pereira, Isabele Frazão Mascarenhas, Vinícius Cooper Capetini, Paulo Michel Pinheiro Ferreira, Marcelo Macedo Rogero, Francisco Leonardo Torres-Leal

Journal: Critical reviews in oncology/hematology 2022;179():103796

PMID: 36049616

Full Text on Elsevier Science View on PubMed

Abstract

Breast cancer (BC) diagnosis has been associated with significant risk factors, including family history, late menopause, obesity, poor eating habits, and alcoholism. Despite the advances in the last decades regarding cancer treatment, some obstacles still hinder the effectiveness of therapy. For example, chemotherapy resistance is common in locally advanced or metastatic cancer, reducing treatment options and contributing to mortality. In this review, we provide an overview of BC metabolic changes, including the impact of restrictive diets associated with chemoresistance, the therapeutic potential of the diet on tumor progression, pathways related to metabolic health in oncology, and perspectives on the future in the area of oncological nutrition.

Address: Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piauí, Teresina, Brazil.; Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil.; Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piauí, Teresina, Brazil.; Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN), Department of Biophysics and Physiology, Center for Health Sciences, Federal University of Piauí, Teresina, Brazil. Electronic address: [email protected].

DOI: 10.1016/j.critrevonc.2022.103796

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MeSH Terms: Breast Neoplasms, Cellular Reprogramming, Diet, Drug Resistance, Neoplasm, Female, Humans, Obesity