Nutraceuticals and blood pressure control: a European Society of Hypertension position document.

Dragan Lovic, Giuseppe Mancia, Philippe Van De Borne, Josep Redon, Jorge Polonia, Bojan Jelakovic, Reinhold Kreutz, Thomas Kahan, Empar Lurbe, Claudio Borghi, Guido Grassi, Giovambattista Desideri, Antonio Coca, Denis Clement, Arrigo F G Cicero, Michel Burnier, Enrico Agabiti-Rosei, Konstantinos Tsioufis

Journal: Journal of hypertension 2021;38(5):799-812

PMID: 31977574

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Abstract

: High-normal blood pressure (BP) is associated with an increased risk of cardiovascular disease, however the cost-benefit ratio of the use of antihypertensive treatment in these patients is not yet clear. Some dietary components and natural products seems to be able to significantly lower BP without significant side effects. The aim of this position document is to highlight which of these products have the most clinically significant antihypertensive action and wheter they could be suggested to patients with high-normal BP. Among foods, beetroot juice has the most covincing evidence of antihypertensive effect. Antioxidant-rich beverages (teas, coffee) could be considered. Among nutrients, magnesium, potassium and vitamin C supplements could improve BP. Among nonnutrient-nutraceuticals, soy isoflavones could be suggested in perimenopausal women, resveratrol in insulin-resistant patients, melatonin in study participants with night hypertension. In any case, the nutracutical approach has never to substitute the drug treatment, when needed.

Address: Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.; First Cardiology Clinic, Medical School, Hippokration Hospital, National and Kapodistrian University of Athens, Athens, Greece.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.; Service of Nephrology and Hypertension, Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.; Ghent University Hospital, Ghent, Belgium.; Unidad de Hipertensión y Riesgo Vascular, Servicio de Medicina Interna, Hospital Clínico, Universidad de Barcelona, Barcelona, Spain.; Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila.; Department of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.; Clinic for Internal Disease Intermedica, Cardiology Department, Hypertension, Nis, Serbia.; Departamento de Pediatría, Consorcio Hospital General Universitario, Universidad de Valencia, Valencia, Spain.; Department of Clinical Sciences, Karolinska Institute, Stockholm, Sweden.; Institut für Klinische Pharmakologie und Toxikologie, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Department of Nephrology, Hypertension, Dialysis and Transplantation, University of Zagreb School of Medicine, University Hospital Center Zagreb, Zagreb, Croatia.; Department of Medicine and CINTESIS, Faculty of Medicine, University of Porto, Porto, Portugal.; Servicio de Medicina Interna del Hospital Clínico de Valencia, Catedrático de Medicina de la Universidad de Valencia, Valencia, Spain.; Service de Cardiologie, Université Libre de Bruxelles - Hôpital Erasme, Brussels, Belgium.; IRCCS Instituto Auxologico Italiano, University of Milano-Bicocca, Milano, Italy.

DOI: 10.1097/HJH.0000000000002353

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MeSH Terms: Antihypertensive Agents, Antioxidants, Beverages, Blood Pressure, Dietary Supplements, Humans, Hypertension, Magnesium, Melatonin, Potassium, Prehypertension