Recent advances in cytoplasmic lipid droplet metabolism in intestinal enterocyte.

Murooj Ghanem, Gary F Lewis, Changting Xiao

Journal: Biochimica et biophysica acta. Molecular and cell biology of lipids 2022;1867(10):159197

PMID: 35820577

Full Text on Elsevier Science View on PubMed

Abstract

Processing of dietary fats in the intestine is a highly regulated process that influences whole-body energy homeostasis and multiple physiological functions. Dysregulated lipid handling in the intestine leads to dyslipidemia and atherosclerotic cardiovascular disease. In intestinal enterocytes, lipids are incorporated into lipoproteins and cytoplasmic lipid droplets (CLDs). Lipoprotein synthesis and CLD metabolism are inter-connected pathways with multiple points of regulation. This review aims to highlight recent advances in the regulatory mechanisms of lipid processing in the enterocyte, with particular focus on CLDs. In-depth understanding of the regulation of lipid metabolism in the enterocyte may help identify therapeutic targets for the treatment and prevention of metabolic disorders.

Address: Department of Anatomy, Physiology and Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.; Departments of Medicine and Physiology, University of Toronto, and University Health Network, Toronto, ON, Canada.; Department of Anatomy, Physiology and Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada. Electronic address: [email protected].

DOI: 10.1016/j.bbalip.2022.159197

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MeSH Terms: Cytosol, Dietary Fats, Enterocytes, Lipid Droplets, Lipid Metabolism