Dehazing redox homeostasis to foster purple bacteria biotechnology.

Abbas Alloul, Naïm Blansaer, Paloma Cabecas Segura, Ruddy Wattiez, Siegfried E Vlaeminck, Baptiste Leroy

Journal: Trends in biotechnology 2022;41(1):106-119

PMID: 35843758

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Abstract

Purple non-sulfur bacteria (PNSB) show great potential for environmental and industrial biotechnology, producing microbial protein, biohydrogen, polyhydroxyalkanoates (PHAs), pigments, etc. When grown photoheterotrophically, the carbon source is typically more reduced than the PNSB biomass, which leads to a redox imbalance. To mitigate the excess of electrons, PNSB can exhibit several 'electron sinking' strategies, such as CO fixation, N fixation, and H and PHA production. The lack of a comprehensive (over)view of these redox strategies is hindering the implementation of PNSB for biotechnology applications. This review aims to present the state of the art of redox homeostasis in phototrophically grown PNSB, presenting known and theoretically expected strategies, and discussing them from stoichiometric, thermodynamic, metabolic, and economic points of view.

Address: Research Group of Sustainable Energy, Air and Water Technology, Department of Bioscience Engineering, University of Antwerp, Antwerpen, Belgium. Electronic address: [email protected].; Research Group of Sustainable Energy, Air and Water Technology, Department of Bioscience Engineering, University of Antwerp, Antwerpen, Belgium.; Laboratory of Proteomics and Microbiology, University of Mons, Mons, Belgium.

DOI: 10.1016/j.tibtech.2022.06.010

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MeSH Terms: Proteobacteria, Biotechnology, Polyhydroxyalkanoates, Oxidation-Reduction, Homeostasis