Malignant Transformation in Glottic Dysplasia Treated With Photoangiolytic LASER - A Systematic Review and Meta-analysis.

Rachel H Jonas, Taylor Lear, Andrew Zaninovich, Cate Joshua, Patrick O McGarey

Journal: Journal of voice : official journal of the Voice Foundation 2025;39(1):230-237

PMID: 35850887

Full Text on Elsevier Science View on PubMed

Abstract

OBJECTIVE

This systematic review and meta-analysis seeks to characterize the rate of malignant progression among patients with laryngeal dysplasia treated with photoangiolytic laser and compare to prior systematic reviews of conventional surgical approaches.

METHODS

OVIDMedline, Pubmed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Google Scholar were searched, including terms related to patients with vocal fold dysplasia who were treated by angiolytic laser ablation. Some articles already known to authors or identified through hand searching were included.

RESULTS

Six articles with 155 cases were included. Two studies used potassium titanyl phosphate exclusively, one solely used the pulsed dye laser, and three studies utilized both laser types during the study period. The pooled overall mean of malignant progression for patients with laryngeal dysplasia treated with photoangiolytic laser was 12%, as calculated by conducting a meta-analysis of single arm proportion.

CONCLUSION

Laryngeal dysplasia is a premalignant lesion which confers a risk of progression to malignancy. After biopsy to establish the diagnosis there are multiple surgical techniques available for treatment with the goal of lesion eradication and voice preservation. In our review, there is a low malignant transformation rate for patients treated via with photoangiolytic laser.

Address: Department of Otolaryngology, Head and Neck Surgery, University of Virginia, Charlottesville, Virginia. Electronic address: [email protected].; University of Virginia, School of Medicine, Charlottesville, Virginia.; University of Virginia, Health Sciences Library, Charlottesville, Virginia.; Department of Otolaryngology, Head and Neck Surgery, University of Virginia, Charlottesville, Virginia.

DOI: 10.1016/j.jvoice.2022.06.020

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MeSH Terms: Humans, Laryngeal Neoplasms, Cell Transformation, Neoplastic, Glottis, Laser Therapy, Precancerous Conditions, Treatment Outcome, Risk Factors, Disease Progression, Lasers, Solid-State, Vocal Cords, Male, Lasers, Dye, Female