Antiretroviral therapy initiation within 7 and 8-30 days post-HIV diagnosis demonstrates similar benefits in resource-limited settings.

Bin Zhao, Haibo Ding, Wei Song, Mingming Kang, Xue Dong, Xin Li, Lu Wang, Jianmin Liu, Zhenxing Chu, Lin Wang, Wen Tian, Yu Qiu, Hong Shang, Xiaoxu Han

Journal: AIDS (London, England) 2022;36(12):1741-1743

PMID: 35866529

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Abstract

We estimated the optimum time to initiate antiretroviral therapy (ART) in a retrospective observational cohort. We observed that ART initiation 7 days or less ( n = 817) and 8-30 days ( n = 1009) were the most important factors with viral suppression, and had similar viral suppression rate, CD4 + T-cell count increase and fractions of individuals with links at least 4 and individuals linked to recent HIV infection in HIV molecular networks. This study provides real-world evidence on the benefits of rapid ART initiation in resource-limited setting.

Address: NHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University.; Laboratory Medicine Innovation Unit, Chinese Academy of Medical Sciences.; Key Laboratory of AIDS Immunology of Liaoning Province, Shenyang.; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou.; Department of Food Safety and Nutrition, Shenyang Center for Health Service and Administrative Law Enforcement (Shenyang Center for Disease Control and Prevention), Shenyang, China.

DOI: 10.1097/QAD.0000000000003327

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MeSH Terms: Anti-HIV Agents, CD4 Lymphocyte Count, Cohort Studies, HIV Infections, Humans, Retrospective Studies, Viral Load