Interplay between cellular metabolism and DNA viruses.

Milad Zandi, Somayeh Shokri, Shahab Mahmoudvand, Ahmad Hosseinzadeh Adli, Ramin Mohammadi, Azita Haddadi

Journal: Journal of medical virology 2022;94(11):5163-5173

PMID: 35869415

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Abstract

Viruses as intracellular pathogens take over the host metabolism and reprogram to facilitate optimal virus production. DNA viruses can cause alterations in several metabolic pathways, including aerobic glycolysis also known as the Warburg effect, pentose phosphate pathway activation, and amino acid catabolism such as glutaminolysis, nucleotide biosynthesis, lipid metabolism, and amino acid biosynthesis. The available energy for productive infection can be increased in infected cells via modification of different carbon source utilization. This review discusses the metabolic alterations of the DNA viruses that will be the basis for future novel therapeutic approaches.

Address: Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.; Department of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.; Department of Bacteriology and Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

DOI: 10.1002/jmv.28018

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MeSH Terms: Amino Acids, DNA Viruses, Glycolysis, Humans, Metabolic Networks and Pathways, Virus Replication, Viruses