Maternal genetic factors in the development of congenital heart defects.

Laura E Mitchell

Journal: Current opinion in genetics & development 2022;76():101961

PMID: 35882070

Full Text on Elsevier Science View on PubMed

Abstract

Congenital heart defects (CHDs) are among the most common, serious birth defects. However, the cause of CHDs is unknown for approximately half of affected individuals and there are few prevention strategies. Although not extensively investigated, maternal genes may contribute to CHD etiology by modifying the effects of maternal exposures (e.g. medications, nutrients), contributing to maternal phenotypes that are associated with an increased risk of CHDs in offspring (e.g. diabetes), or acting as maternal effect genes. Since maternal genes could serve as a target for the primary prevention of CHDs, efforts to further define the contribution of the maternal genome to CHD etiology are warranted.

Address: Department of Epidemiology, Human Genetics and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA. Electronic address: [email protected].

DOI: 10.1016/j.gde.2022.101961

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MeSH Terms: Female, Heart Defects, Congenital, Humans, Maternal Exposure, Risk Factors