New Insights into Chemical and Biological Properties of Funicone-like Compounds.

Maria Michela Salvatore, Marina DellaGreca, Anna Andolfi, Rosario Nicoletti

Journal: Toxins 2022;14(7):466

PMID: 35878204

Abstract

Funicone-like compounds are a homogeneous group of polyketides that, so far, have only been reported as fungal secondary metabolites. In particular, species in the genus seem to be the most typical producers of this group of secondary metabolites. The molecular structure of funicone, the archetype of these products, is characterized by a γ-pyrone ring linked through a ketone group to a α-resorcylic acid nucleus. This review provides an update on the current knowledge on the chemistry of funicone-like compounds, with special emphasis on their classification, occurrence, and diverse biological activities. In addition, their potential relevance as mycotoxins is discussed.

Address: Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.; Institute for Sustainable Plant Protection, National Research Council, 80055 Portici, Italy.; Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.; Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.; BAT Center-Interuniversity Center for Studies on Bioinspired Agro-Environmental Technology, University of Naples Federico II, 80055 Portici, Italy.; Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy.; Council for Agricultural Research and Economics, Research Center for Olive, Fruit, and Citrus Crops, 81100 Caserta, Italy.

DOI: 10.3390/toxins14070466

Link outs

Free resources

Full Text Sources:

MeSH Terms: Penicillium, Polyketides, Pyrones, Talaromyces