Hyaluronic Acid Basics and Rheology.

Grace T Wu, Joanna Kam, Jason D Bloom

Journal: Facial plastic surgery clinics of North America 2022;30(3):301-308

PMID: 35934432

Full Text on Elsevier Science View on PubMed

Abstract

Hyaluronic acid (HA) is the most common dermal filler in use. It improves wrinkles and volume loss not only by filling and volumizing but also by hydrating the injected area with its water affinity. It is a naturally occurring component of skin, and there is a negligible risk of immunologic or allergic reaction with injection. It is rapidly degraded by the injection of hyaluronidase, thus creating an ideal injectable material that is low risk and reversible. Its duration of effect may be longer than expected based on bioavailability of the HA product due to collagen synthesis or fibroblast stimulation.

Address: Department of Otorhinolaryngology, University of Pennsylvania, 3737 Market Street, Suite 302, Philadelphia, PA 19104, USA.; Georgia Center for Facial Plastic Surgery, 613 Ponder Place Drive, Evans, GA 30809, USA.; Department of Otorhinolaryngology, University of Pennsylvania, 3737 Market Street, Suite 302, Philadelphia, PA 19104, USA; Bloom Facial Plastic Surgery, Two Town Place, Suite 110, Bryn Mawr, PA 19010, USA. Electronic address: [email protected].

DOI: 10.1016/j.fsc.2022.03.004

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MeSH Terms: Cosmetic Techniques, Dermal Fillers, Humans, Hyaluronic Acid, Hyaluronoglucosaminidase, Rheology, Skin, Skin Aging