Mechanism of Ion Translocation by Na+-Rhodopsin.

Alexander V Bogachev, Alexander A Baykov, Yulia V Bertsova, Mahir D Mamedov

Journal: Biochemistry. Biokhimiia 2022;87(8):731-741

PMID: 36171654

Abstract

This review provides a brief description of the structure and transport function of the recently discovered family of retinal-containing Na+-translocating rhodopsins. The main emphasis is put on the kinetics of generation of electric potential difference in the membrane during a single transporter turnover. According to the proposed transport mechanism of Na+-rhodopsin, the driving force for the Na+ translocation from the cytoplasm is the local electric field created by the H+ movement from the Schiff base.

Address: Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119234, Russia. [email protected].; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119234, Russia.

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