Recent advances in porous MOFs and their hybrids for photothermal cancer therapy.

Jia Su, Peng Jing, Ke Jiang, Jingjing Du

Journal: Dalton transactions (Cambridge, England : 2003) 2022;51(23):8938-8944

PMID: 35642650

Full Text on Royal Society of Chemistry View on PubMed

Abstract

Cancer is still one of the most life-threatening diseases in the world. Among the various cancer therapeutic strategies, photothermal therapy (PTT) has attracted considerable attention due to its high treatment efficacy, low invasive burden, and minor side effects. Microporous metal-organic frameworks (MOFs) are potential materials for photothermal tumor treatment thanks to their high surface areas, suitable pore geometry, and easy functionalization. Through designating organic linkers, encapsulating PTT agents and fabricating MOF hybrids, MOF-based treatment platforms have great potential in PTT. In this review, we mainly summarize the recent advances of MOFs in photothermal combined cancer therapy. The present challenges and possible future prospects in this field are also explored.

Address: Key Laboratory of Food Nutrition and Functional Food of Hainan Province, School of Food Science and Engineering, Hainan University, Haikou 570228, China. [email protected].; Key Laboratory of Food Nutrition and Functional Food of Hainan Province, School of Food Science and Engineering, Hainan University, Haikou 570228, China. [email protected].; State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027, China.; Analytical & Testing Center, Hainan University, Haikou 570228, China. [email protected].

DOI: 10.1039/d2dt01039a

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https://doi.org/10.1039/d2dt01039a

MeSH Terms: Humans, Metal-Organic Frameworks, Neoplasms, Phototherapy, Photothermal Therapy, Porosity