The Role of Schwann Cells in Cancer.

Sylvie Deborde, Richard J Wong

Journal: Advanced biology 2022;6(9):e2200089

PMID: 35666078

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Abstract

Schwann cells (SCs) are the most abundant cell type in the nerves in the peripheral nervous system and compose a family of subtypes that are endowed with a variety of different functions. SCs facilitate the transmission of neural impulses, provide nutrients and protection for neurons, guide axons in nerve repair, and regulate immune functions. In the context of cancer, recent studies have revealed an active role of SCs in promoting cancer cell invasion, modulating immune responses, and transmitting pain sensation.

Address: Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

DOI: 10.1002/adbi.202200089

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MeSH Terms: Axons, Neoplasms, Nerve Regeneration, Peripheral Nervous System, Schwann Cells