The soil bacterium, Corynebacterium glutamicum, from biosynthesis of value-added products to bioremediation: A master of many trades.

Durga Ray, Uttpal Anand, Niraj Kumar Jha, Ewa Korzeniewska, Elza Bontempi, Jarosław Proćków, Abhijit Dey

Journal: Environmental research 2022;213():113622

PMID: 35710026

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Abstract

Ever since its discovery in 1957, Corynebacterium glutamicum has become a well-established industrial strain and is known for its massive capability of producing various amino acids (like L-lysine and L-glutamate) and other value-added chemicals. With the rising demand for these bio-based products, the revelation of the whole genome sequences of the wild type strains, and the astounding advancements made in the fields of metabolic engineering and systems biology, our perspective of C. glutamicum has been revolutionized and has expanded our understanding of its strain development. With these advancements, a new era for C. glutamicum supremacy in the field of industrial biotechnology began. This led to remarkable progress in the enhancement of tailor-made over-producing strains and further development of the substrate spectrum of the bacterium, to easily accessible, economical, and renewable resources. C. glutamicum has also been metabolically engineered and used in the degradation/assimilation of highly toxic and ubiquitous environmental contaminant, arsenic, present in water or soil. Here, we review the history, current knowledge, progress, achievements, and future trends relating to the versatile metabolic factory, C. glutamicum. This review paper is devoted to C. glutamicum which is one of the leading industrial microbes, and one of the most promising and versatile candidates to be developed. It can be used not only as a platform microorganism to produce different value-added chemicals and recombinant proteins, but also as a tool for bioremediation, allowing to enhance specific properties, for example in situ bioremediation.

Address: Department of Microbiology, St. Aloysius' College, Jabalpur, Madhya Pradesh, 482001, India. Electronic address: [email protected].; Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.; Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, 201310, Uttar Pradesh, India; Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali, 140413, Punjab, India; Department of Biotechnology, School of Applied & Life Sciences, Uttaranchal University, Dehradun 248007, Uttarakhand, India.; Department of Water Protection Engineering and Environmental Microbiology, The Faculty of Geoengineering, University of Warmia and Mazury in Olsztyn, Prawocheńskiego 1 Str., 10-719, Olsztyn, Poland.; INSTM and Chemistry for Technologies Laboratory, Department of Mechanical and Industrial Engineering, University of Brescia, Via Branze, 38, 25123, Brescia, Italy.; Department of Plant Biology, Institute of Environmental Biology, Wrocław University of Environmental and Life Sciences, Kożuchowska 5b, 51-631, Wrocław, Poland. Electronic address: [email protected].; Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, West Bengal, India. Electronic address: [email protected].

DOI: 10.1016/j.envres.2022.113622

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MeSH Terms: Biodegradation, Environmental, Biotechnology, Corynebacterium glutamicum, Metabolic Engineering, Soil