Mohammad Behnam, Alireza Motamedzadeh, Marzieh Aalinezhad, Ehsan Dadgostar, Fatemeh Zahra Rashidi Noshabad, Mohammad Pourfridoni, Maedeh Raei, Hamed Mirzaei, Michael Aschner, Omid Reza Tamtaji
Journal: Molecular biology reports 2022;49(11):10609-10615
PMID: 35715607
Primary brain tumors are a heterogeneous group of tumors that arise from cells intrinsic to the central nervous system (CNS). Aquaporin-4 (AQP4) has been implicated in the pathogenesis of brain tumors. Previous reports have documented a relationship between AQP4 and several molecular pathways associated with the etiology of brain tumors, such as apoptosis, invasion and cell migration. AQP4 affects apoptosis via cytochrome C, Bad and Bcl-2, as well as invasion and migration via IDO1/TDO-Kyn-AhR axis, lncRNA LINC00461, miR-216a, miRNA-320a and MMPs. In addition, inhibition of AQP4 mitigates the progression of brain tumors. This review summarizes current knowledge and evidence regarding the relationship between AQP4 and brain tumors, and the mechanisms involved.
© 2022. The Author(s), under exclusive licence to Springer Nature B.V.
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