Multi-subunit acetyl-CoA carboxylases.

John E Cronan, Grover L Waldrop

Journal: Progress in lipid research 2002;41(5):407-35

PMID: 12121720

Full Text on Elsevier Science View on PubMed

Abstract

Acetyl-CoA carboxylase (ACC) catalyses the first committed step of fatty acid synthesis, the carboxylation of acetyl-CoA to malonyl-CoA. Two physically distinct types of enzymes are found in nature. Bacterial and most plant chloroplasts contain a multi-subunit ACC (MS-ACC) enzyme that is readily dissociated into its component proteins. Mammals, fungi, and plant cytosols contain the second type of ACC, a single large multifunctional polypeptide. This review will focus on the structures, regulation, and enzymatic mechanisms of the bacterial and plant MS-ACCs.

Address: Department of Microbiology, B103 Chemical and Life Sciences Laboratory, University of Illinois, 601 S. Goodwin Avenue, Urbana, IL 61801, USA. [email protected]

DOI: 10.1016/s0163-7827(02)00007-3

Link outs

Free resources

Other Literature Sources:

https://www.lens.org/lens/search/patent/list?q=ref...

Molecular Biology Databases:

https://metacyc.org/gene?orgid=META&id=EG10217

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0163...

MeSH Terms: Acetyl-CoA Carboxylase, Carrier Proteins, Catalysis, Escherichia coli, Fatty Acid Synthase, Type II, Humans, Mutation, Plants, Structure-Activity Relationship