Folic acid effect on homocysteine, sortilin levels and glycemic control in type 2 diabetes mellitus patients.

[{"label":"AIM","text":"The present study aimed to determine the folic acid supplement (FAS) effects on serum homocysteine and sortilin levels, glycemic indices, and lipid profile in type II diabetic patients."},{"label":"METHOD","text":"A double-blind randomized controlled clinical trial have been performed on 100 patients with T2DM randomly divided into two groups that received either placebo or folic acid 5\u2009mg\/d for 12 weeks."},{"label":"RESULTS","text":"FAS caused a significant decrease in homocysteine and sortilin serum levels (28.2% and 33.7%, P\u2009<\u20090.0001, respectively). After 3 months of intervention, 8.7% decrease in fasting blood glucose (P\u2009=\u20090.0005), 8.2% in HbA1c (P\u2009=\u20090.0002), 13.7% in serum insulin (P\u2009<\u20090.0001) and 21.7% in insulin resistance (P\u2009<\u20090.0001) were found in the folic acid group, however no significant difference was observed in the placebo group. Serum hs-CRP level showed significant positive associations with sortilin (r\u2009=\u20090.237, P\u2009=\u20090.018), homocysteine (r\u2009=\u20090.308, P\u2009=\u20090.002) and fasting blood glucose (r\u2009=\u20090.342, P\u2009=\u20090.000). There were no significant changes in lipid profile in both groups after 12 weeks."},{"label":"CONCLUSION","text":"FAS might be beneficial for reducing homocysteine and sortilin levels, enhancing glycemic control, and improved insulin resistance in patients with T2DM."},{"copyright":"\u00a9 2022. The Author(s)."}]