An update on adrenocortical cell lines of human origin.

Sandra Sigala, Elisa Rossini, Andrea Abate, Mariangela Tamburello, Stefan R Bornstein, Constanze Hantel

Journal: Endocrine 2022;77(3):432-437

PMID: 35764904

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Abstract

Adrenocortical carcinoma (ACC) is a rare, heterogenous and highly malignant disease. Management of ACC is dependent on disease stage with complete surgical resection as the only potentially curative option. However, advanced, un-resectable, metastatic stages and also recurrences often require systemic treatments, which are unfortunately nowadays still unsatisfactory. The scarcity of preclinical models reflecting patient heterogeneities and furthermore drug-resistant phenotypes, has hampered the progress and development of new therapies in recent years. In this review, we provide an overview on the classical models and substantial progress which has been made over the last years in context of this aggressive disease.

Address: Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, 25124, Brescia, Italy.; Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), 8091, Zürich, Switzerland.; Medizinische Klinik und Poliklinik III, University Hospital Carl Gustav Carus Dresden, 01307, Dresden, Germany.; Diabetes and Nutritional Sciences, King's College London, London, WC2R 2LS, UK.; Center for Regenerative Therapies, Technische Universität Dresden, 01307, Dresden, Germany.; Paul-Langerhans-Institute Dresden, Helmholtz Center Munich, University Hospital Carl Gustav Carus, Faculty of Medicine, Technische Universität Dresden, 01307, Dresden, Germany.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 636921, Singapore.; Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), 8091, Zürich, Switzerland. [email protected].; Medizinische Klinik und Poliklinik III, University Hospital Carl Gustav Carus Dresden, 01307, Dresden, Germany. [email protected].

DOI: 10.1007/s12020-022-03112-w

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MeSH Terms: Adrenal Cortex Neoplasms, Adrenocortical Carcinoma, Cell Line, Humans