Biliary Atresia in Children: Update on Disease Mechanism, Therapies, and Patient Outcomes.

Swati Antala, Sarah A Taylor

Journal: Clinics in liver disease 2022;26(3):341-354

PMID: 35868678

Free Full Text on PubMed Central View on PubMed

Abstract

Biliary atresia is a rare disease but remains the most common indication for pediatric liver transplantation as there are no effective medical therapies to slow progression after diagnosis. Variable contribution of genetic, immune, and environmental factors contributes to disease heterogeneity among patients with biliary atresia. Developing a deeper understanding of the disease mechanism will help to develop targeted medical therapies and improve patient outcomes.

Address: Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Ann and Robert H Lurie Children's Hospital of Chicago, 225 East Chicago Avenue, Box 65, Chicago, IL 60611, USA.; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Ann and Robert H Lurie Children's Hospital of Chicago, 225 East Chicago Avenue, Box 65, Chicago, IL 60611, USA. Electronic address: [email protected].

DOI: 10.1016/j.cld.2022.03.001

Link outs

Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/livertransplantation.html

Subscription / membership required

Full Text Sources:

MeSH Terms: Biliary Atresia, Child, Humans, Infant, Liver Transplantation