Autoimmune hepatitis in pediatrics, a review by the Working Group of the Latin American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

Margarita Ramonet, Nelson Ramirez-Rodriguez, Felipe Álvarez Chávez, María C Arregui, Gustavo Boldrini, Verónica Botero Osorio, Miriam Cuarterolo, Marcela Godoy, Fernando Alonso Medina Monroy, Gabriela Oropeza, Rosana Pérez Carusi, Diana Pérez Rodríguez, Fátima Azereth Reynoso-Zarzosa, Mirta Ciocca

Journal: Archivos argentinos de pediatria 2022;120(4):281-287

PMID: 35900956

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Abstract

Autoimmune hepatitis (AIH) is a chronic inflammatory condition of the liver characterized by a complex interaction among genetic factors, immune response to antigens present in hepatocytes, and immune regulation alterations. Its distribution is global and there is a female predominance. AIH is divided into 2 groups, depending on the type of serum autoantibodies detected. The most common presentation is acute hepatitis (40%), with non-specific symptoms, high aminotransferase levels, and hypergammaglobulinemia. Standard treatment consists of the administration of immunosuppressive drugs. It is a complex condition, often difficult to diagnose. If not managed adequately, the 5-year mortality rate may reach 75%.

Sociedad Argentina de Pediatría.

Address: Comité Nacional de Hepatología, Sociedad Argentina de Pediatría. [email protected].; Universidad Mayor de San Andrés, Hospital del Seguro Social Universitario, Bolivia.; Unidad Médica de Alta Especialidad, Hospital de Pediatría, Centro Médico Nacional de Occidente, IMSS, Guadalajara, México.; Hospital de Niños Sor María Ludovica, La Plata, Argentina.; Hospital Italiano de Buenos Aires, Argentina.; Fundación Valle del Lili, Cali, Colombia.; Hospital de Pediatría Prof. Dr. Juan P. Garrahan, Ciudad Autónoma de Buenos Aires, Argentina.; Hospital Clínico San Borja Arriarán, Santiago, Chile.; Centro Médico UGANEP, Bucaramanga, Colombia.; https://orcid.org/0000-0003-0210-7242.; Hospital Alemán y Hospital El Cruce. Buenos Aires, Argentina.; Instituto Nacional de Salud del Niño-San Borja. Perú.; Hospital Universitario de Puebla, BUAP, México.; Hospital Alemán de Buenos Aires, Argentina.

DOI: 10.5546/aap.2022.eng.281

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https://doi.org/10.5546/aap.2022.eng.281

MeSH Terms: Autoantibodies, Child, Female, Gastroenterology, Hepatitis, Autoimmune, Humans, Latin America, Male