Docetaxel secretion in tears: association with lacrimal drainage obstruction.

Bita Esmaeli, M Amir Ahmadi, Edgardo Rivera, Vicente Valero, Toni Hutto, Denise M Jackson, Robert A Newman

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 2002;120(9):1180-2

PMID: 12215091

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Abstract

OBJECTIVE

To test the hypothesis that docetaxel may be secreted in tears after intravenous infusion.

DESIGN

Prospective pilot trial.

PATIENTS AND METHODS

Tear fluid was collected from 4 patients receiving docetaxel weekly and 2 patients receiving docetaxel every 3 weeks as a single agent for the treatment of metastatic breast cancer. Tear samples were collected once prior to and again within 30 minutes following the end of the 1-hour docetaxel infusion. A blood sample was also obtained after infusion. The tear and plasma samples were analyzed for drug content using high-performance liquid chromatography and tandem mass spectrometry.

RESULTS

Docetaxel was found in the tear samples collected from all 6 patients.

CONCLUSION

The secretion of docetaxel in tears may be a mechanism for canalicular inflammation and tear drainage obstruction, which are known to occur as an adverse effect of the drug.

Address: Ophthalmology Section, Department of Plastic Surgery, Box 443, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. [email protected]

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MeSH Terms: Aged, Antineoplastic Agents, Phytogenic, Breast Neoplasms, Chromatography, High Pressure Liquid, Docetaxel, Female, Gas Chromatography-Mass Spectrometry, Humans, Infusions, Intravenous, Lacrimal Duct Obstruction, Middle Aged, Paclitaxel, Pilot Projects, Prospective Studies, Taxoids, Tears