Cassane-type diterpenes from roots of Pterolobium macropterum and their anti-inflammatory activity.

Achara Raksat, Siwattra Choodej, Thammarat Aree, Samad Nejad Ebrahimi, Khanitha Pudhom

Journal: Phytochemistry 2022;196():113074

PMID: 34990974

Full Text on Elsevier Science View on PubMed

Abstract

Eight undescribed cassane diterpenes, pterolobirins C-J, together with two known analogs, were isolated from the roots of Pterolobium macropterum. Their structures were characterized by extensive spectroscopic techniques including NMR, MS, ECD and X-ray crystallographic spectroscopy. The absolute configuration of pterolobirin J was confirmed by single-crystal X-ray diffraction data. The compounds were screened for their anti-inflammatory activity on the lipopolysaccharide (LPS) induced nitric oxide (NO) production in J774. A1 macrophage cells. Pterolobirin E and sucutinirane C displayed good NO inhibition with IC values of 24.44 ± 1.34 and 19.16 ± 1.22 μM, respectively.

Address: Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.; Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran, Iran. Electronic address: [email protected].; Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand. Electronic address: [email protected].

DOI: 10.1016/j.phytochem.2021.113074

Link outs

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0031...

MeSH Terms: Anti-Inflammatory Agents, Caesalpinia, Diterpenes, Magnetic Resonance Spectroscopy, Molecular Structure, Nitric Oxide