Carbonic anhydrase for CO capture, conversion and utilization.

Sachin Talekar, Byung Hoon Jo, Jonathan S Dordick, Jungbae Kim

Journal: Current opinion in biotechnology 2022;74():230-240

PMID: 34992045

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Abstract

Carbonic anhydrase (CA) enzymes, catalyzing the CO hydration at a high turnover number, can be employed in expediting CO capture, conversion and utilization to aid in carbon neutrality. Despite extensive research over the last decade, there remain challenges in CA-related technologies due to poor stability and suboptimal use of CAs. Herein, we discuss recent advances in CA stabilization by protein engineering and enzyme immobilization, and shed light on state-of-the-art of in vitro and in vivo CA-mediated CO conversion for improved production of value-added chemicals using CO as a feedstock.

Address: Department of Chemical and Biological Engineering, Korea University, Seoul 02841, Republic of Korea.; Division of Life Science and Research Institute of Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea.; Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy 12180, NY, USA. Electronic address: [email protected].; Department of Chemical and Biological Engineering, Korea University, Seoul 02841, Republic of Korea. Electronic address: [email protected].

DOI: 10.1016/j.copbio.2021.12.003

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MeSH Terms: Carbon Dioxide, Carbonic Anhydrases, Enzymes, Immobilized