The PASTA domain: a beta-lactam-binding domain.

Corin Yeats, Robert D Finn, Alex Bateman

Journal: Trends in biochemical sciences 2002;27(9):438

PMID: 12217513

Full Text on Elsevier Science View on PubMed

Abstract

The PASTA domain (for penicillin-binding protein and serine/threonine kinase associated domain) is found in the high molecular weight penicillin-binding proteins and eukaryotic-like serine/threonine kinases of a range of pathogens. We describe this previously uncharacterized domain and infer that it binds beta-lactam antibiotics and their peptidoglycan analogues. We postulate that PknB-like kinases are key regulators of cell-wall biosynthesis. The essential function of these enzymes suggests an additional pathway for the action of beta-lactam antibiotics.

Address: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK CB10 1SA. [email protected]

DOI: 10.1016/s0968-0004(02)02164-3

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MeSH Terms: Amino Acid Sequence, Anti-Bacterial Agents, Bacterial Proteins, Carrier Proteins, Databases, Protein, Hexosyltransferases, Molecular Sequence Data, Muramoylpentapeptide Carboxypeptidase, Penicillin-Binding Proteins, Peptidyl Transferases, Protein Binding, Protein Serine-Threonine Kinases, Protein Structure, Tertiary, Sequence Alignment, beta-Lactams