The central nervous system control of energy homeostasis: High fat diet induced hypothalamic microinflammation and obesity.

Lihong Yan, Juxue Li

Journal: Brain research bulletin 2022;185():99-106

PMID: 35525336

Full Text on Elsevier Science View on PubMed

Abstract

Obesity is believed to arise through the imbalance of energy homeostasis controlled by the central nervous system, where the hypothalamus plays the fundamental role in energy metabolism. In this review, we will provide an overview regarding the functions of POMC neurons and AgRP neurons in acute nucleus of the hypothalamus which mediated the energy metabolism, highlighting their interactions with peripheral organs derived hormones in control of energy homeostasis. Furthermore, the role of high fat diet induced hypothalamic microinflammation in the pathogenesis of obesity will be discussed. We hope this review could help researchers to understand the mechanism of hypothalamus in control of energy metabolism, and design related drugs to block the pathways involving in the impaired metabolism in obese patients.

Address: State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu 211166, China.; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu 211166, China; The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address: [email protected].

DOI: 10.1016/j.brainresbull.2022.04.015

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MeSH Terms: Diet, High-Fat, Energy Metabolism, Homeostasis, Humans, Hypothalamus, Obesity, Pro-Opiomelanocortin