Coenzymes and the primary and specialized metabolism interface.

Maite Colinas, Teresa B Fitzpatrick

Journal: Current opinion in plant biology 2022;66():102170

PMID: 35063913

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Abstract

In plants, primary and specialized metabolism have classically been distinguished as either essential for growth or required for survival in a particular environment. Coenzymes (organic cofactors) are essential for growth but their importance to specialized metabolism is often not considered. In line with the recent proposal of viewing primary and specialized metabolism as an integrated whole rather than segregated lots with a defined interface, we highlight here the importance of collating information on the regulation of coenzyme supply with metabolic demands using examples of vitamin B derived coenzymes. We emphasize that coenzymes can have enormous influence on the outcome of metabolic as well as engineered pathways and should be taken into account in the era of synthetic biology.

Address: Department of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Hans-Knöll-Straße 80, D-07745 Jena, Germany. Electronic address: [email protected].; Department of Botany and Plant Biology, University of Geneva, Quai Ernest-Ansermet 30, CH-1211 Geneva 4, Switzerland. Electronic address: [email protected].

DOI: 10.1016/j.pbi.2021.102170

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https://medlineplus.gov/bvitamins.html

MeSH Terms: Coenzymes, Plants, Vitamin B Complex