The clinical aspect of NTRK-fusions in pediatric papillary thyroid cancer.

Julio C Ricarte-Filho, Stephen Halada, Alison O'Neill, Victoria Casado-Medrano, Theodore W Laetsch, Aime T Franco, Andrew J Bauer

Journal: Cancer genetics 2022;262-263():57-63

PMID: 35092884

Free Full Text on PubMed Central View on PubMed

Abstract

Although adult and pediatric papillary thyroid cancer (PTC) share similar oncogenic drivers, they differ in the pathological features and outcomes of the disease. In adults with PTC, the most frequent genetic alterations are mutually exclusive point mutations in BRAF or the RAS family with BRAF commonly associated with invasive disease and decreased response to radioiodine therapy. In pediatric PTC, fusion oncogenes involving chromosomal translocations in tyrosine kinase (TK) receptors, most commonly RET and NTRK, are often found in patients with lateral neck and distant metastases. This brief report reviews clinical data from a single-institute's cohort of NTRK-driven pediatric PTC cases with an updated review of the literature and comparison to adult NTRK-driven PTC.

Address: Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, 3500 Civic Center Boulevard, Buerger Center, 12-149, Philadelphia, PA 19104, United States.; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, United States; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, 3500 Civic Center Boulevard, Buerger Center, 12-149, Philadelphia, PA 19104, United States; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, 3500 Civic Center Boulevard, Buerger Center, 12-149, Philadelphia, PA 19104, United States. Electronic address: [email protected].

DOI: 10.1016/j.cancergen.2022.01.002

Link outs

Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/thyroidcancer.html

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-BRAF-6

Subscription / membership required

Full Text Sources:

MeSH Terms: Adult, Child, Gene Fusion, Humans, Iodine Radioisotopes, Mutation, Proto-Oncogene Proteins B-raf, Thyroid Cancer, Papillary, Thyroid Neoplasms