Aquaporin-5 in breast cancer.

Malte Bystrup, Frédéric H Login, Sarannya Edamana, Signe Borgquist, Trine Tramm, Tae-Hwan Kwon, Lene N Nejsum

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2022;130(5):253-260

PMID: 35114014

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Abstract

The water channel aquaporin-5 (AQP5) is essential in transepithelial water transport in secretory glands. AQP5 is ectopically overexpressed in breast cancer, where expression is associated with lymph node metastasis and poor prognosis. Besides the role in water transport, AQP5 has been found to play a role in cancer metastasis, migration, and proliferation. AQP5 has also been shown to be involved in the dysregulation of epithelial cell-cell adhesion; frequently observed in cancers. Insight into the underlying molecular mechanisms of how AQP5 contributes to cancer development and progression is essential for potentially implementing AQP5 as a prognostic biomarker and to develop targeted intervention strategies for the treatment of breast cancer patients.

Address: Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark.; Department of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark.; Department of Oncology, Aarhus University Hospital, Aarhus N, Denmark.; Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden.; Department of Pathology, Aarhus University Hospital, Aarhus N, Denmark.; Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Taegu, Korea.

DOI: 10.1111/apm.13212

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MeSH Terms: Aquaporin 5, Breast Neoplasms, Cell Adhesion, Female, Humans, Lymphatic Metastasis, Water