Antifibrotic effect of brown algae-derived fucoidans on osteoarthritic fibroblast-like synoviocytes.

María Piñeiro-Ramil, Noelia Flórez-Fernández, Olalla Ramil-Gómez, María Dolores Torres, Herminia Dominguez, Francisco J Blanco, Rosa Meijide-Faílde, Carlos Vaamonde-García

Journal: Carbohydrate polymers 2022;282():119134

PMID: 35123730

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Abstract

Synovial fibrosis is a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders. Fucoidans, sulfated polysaccharides found in brown algae, have recently emerged as promising therapeutic agents. Despite the increasing amount of evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders, the effect of these sulfated polysaccharides on synovial fibrosis has not been investigated yet. By an in vitro experimental approach in fibroblast-like synoviocytes, we detected that fucoidans inhibit their differentiation into myofibroblasts with tumor cell-like characteristics and restore apoptosis. Composition and structure of fucoidan appear to be critical for the detected activity. Furthermore, protective effects of these sulfated polysaccharides are mediated by upregulation of nitric oxide production and modulation of TGF-β/smad pathway. Altogether, our results support the use of fucoidans as therapeutic compounds in the treatment of the fibrotic processes involved in rheumatic pathologies.

Address: Universidade da Coruña, Tissue Engineering and Cellular Therapy Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Centro de Investigaciones Científicas Avanzadas (CICA), 15006 A Coruña, Spain. Electronic address: [email protected].; CINBIO, Universidade de Vigo, Biomass and Sustanaible Development Group (EQ2), Departament of Chemical Engineering, 32004 Ourense, Spain. Electronic address: [email protected].; Aging and Inflammation Research Laboratory, Instituto de Investigaciones Biomédicas de A Coruña (INIBIC), 15006 A Coruña, Spain; Universidade de Coruña, Endocrine, Nutritional and Metabolic Diseases Group, Departamento de Fisioterapia, Medicina y Ciencias Biomédicas, Facultad de Ciencias de la Salud, 15006 A Coruña, Spain. Electronic address: [email protected].; CINBIO, Universidade de Vigo, Biomass and Sustanaible Development Group (EQ2), Departament of Chemical Engineering, 32004 Ourense, Spain. Electronic address: [email protected].; CINBIO, Universidade de Vigo, Biomass and Sustanaible Development Group (EQ2), Departament of Chemical Engineering, 32004 Ourense, Spain. Electronic address: [email protected].; Universidade da Coruña, Grupo de Investigacion en Reumatología y Salud, Centro de Investigaciones Científicas Avanzadas (CICA), Departamento de Fisioterapia, Medicina y Ciencias Biomédicas, Facultad de Fisioterapia, 15006 A Coruña, Spain; Hospital Universitario A Coruña, Instituto de Investigación Biomédica de A Coruña (INIBIC), Grupo de Investigacion en Reumatología, 15006 A Coruña, Spain. Electronic address: [email protected].; Universidade da Coruña, Tissue Engineering and Cellular Therapy Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Centro de Investigaciones Científicas Avanzadas (CICA), 15006 A Coruña, Spain; Universidade da Coruña, Departamento de Fisioterapia, Medicina y Ciencias Biomédicas, Facultad de Ciencias de la Salud, 15006 A Coruña, Spain. Electronic address: [email protected].; Universidade da Coruña, Grupo de Investigacion en Reumatología y Salud, Centro de Investigaciones Científicas Avanzadas (CICA), Departamento de Biología, Facultad de Ciencias, 15071 A Coruña, Spain. Electronic address: [email protected].

DOI: 10.1016/j.carbpol.2022.119134

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MeSH Terms: Aged, Aged, 80 and over, Apoptosis, Cell Movement, Cell Proliferation, Cells, Cultured, Extracellular Matrix Proteins, Female, Fibroblasts, Fibrosis, Humans, Male, Osteoarthritis, Phaeophyceae, Polysaccharides, Synoviocytes, Transforming Growth Factor beta