NLRP1 Inflammasome Activation in Keratinocytes: Increasing Evidence of Important Roles in Inflammatory Skin Diseases and Immunity.

Gabriele Fenini, Tugay Karakaya, Paulina Hennig, Michela Di Filippo, Marta Slaufova, Hans-Dietmar Beer

Journal: The Journal of investigative dermatology 2022;142(9):2313-2322

PMID: 35550825

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Abstract

In 2007, it was shown that DNA sequence variants of the human NLRP1 gene are associated with autoimmune and autoinflammatory diseases affecting mainly the skin. However, at that time, the underlying cellular and molecular mechanisms were poorly characterized. Meanwhile, increasing evidence suggests that the NLRP1 inflammasome expressed by keratinocytes not only plays a part in the pathology of common inflammatory skin diseases and cancer development but also contributes to skin immunity. Understanding the mechanisms regulating NLRP1 activation in keratinocytes and the downstream events in human skin might pave the way for developing novel strategies for treating patients suffering from NLRP1-mediated skin diseases.

Address: Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland; Faculty of Medicine, University of Zurich, Zurich, Switzerland.; Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland; Faculty of Medicine, University of Zurich, Zurich, Switzerland. Electronic address: [email protected].

DOI: 10.1016/j.jid.2022.04.004

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https://medlineplus.gov/skinconditions.html

MeSH Terms: Adaptor Proteins, Signal Transducing, Apoptosis Regulatory Proteins, Dermatitis, Humans, Inflammasomes, Keratinocytes, NLR Proteins, Skin Diseases