Defining and assessing intrinsic capacity in older people: A systematic review and a proposed scoring system.

Susana López-Ortiz, Simone Lista, Saúl Peñín-Grandes, Jose Pinto-Fraga, Pedro L Valenzuela, Robert Nisticò, Enzo Emanuele, Alejandro Lucia, Alejandro Santos-Lozano

Journal: Ageing research reviews 2022;79():101640

PMID: 35569785

Full Text on Elsevier Science View on PubMed

Abstract

INTRODUCTION

The World Health Organization has introduced the term 'intrinsic capacity' (IC) as a marker of healthy ageing. However, controversy exists on the definition and assessment of IC. We aimed to review the definitions and methods used for the assessment of IC in older adults. In addition, we proposed a new IC scoring method.

METHODS

A systematic search was performed in PubMed, Web of Science, Cochrane Library, Scopus and SPORTDiscus (up to February 10th, 2022) for studies assesing IC in older adults (>60 years).

RESULTS

Thirty-three studies were included. There is overall consensus on the definition of IC as well as on its different dimensions, that is: locomotion, vitality, sensory, cognition and psychological. However, the methods for assessing each of these five dimensions differ substantially across studies and there is no consensus on the best method to compute an eventual global compound score to evaluate IC taking into account all its different dimensions.

CONCLUSIONS

The IC represents a highly relevant clinical concept that has been unfortunately underutilized. We propose a standardization for the assessment of each dimension of IC, with a global 0 (worst) to 10 (highest) score.

Address: i+HeALTH, European University Miguel de Cervantes, 47012 Valladolid, Spain. Electronic address: [email protected].; Faculty of Sport Sciences, European University of Madrid, Villaviciosa de Odón, 28670 Madrid, Spain; School of Pharmacy, University of Rome "Tor Vergata", 00133 Rome, Italy.; i+HeALTH, European University Miguel de Cervantes, 47012 Valladolid, Spain.; Research Institute of the Hospital 12 de Octubre ('imas12'), 28041 Madrid, Spain.; School of Pharmacy, University of Rome "Tor Vergata", 00133 Rome, Italy; Laboratory of Pharmacology of Synaptic Plasticity, EBRI Rita Levi-Montalcini Foundation, 00161 Rome, Italy.; 2E Science, Robbio, 27038 Pavia, Italy.; Faculty of Sport Sciences, European University of Madrid, Villaviciosa de Odón, 28670 Madrid, Spain; Research Institute of the Hospital 12 de Octubre ('imas12'), 28041 Madrid, Spain; CIBER en Fragilidad y Envejecimiento Saludable (CIBERFES), 28029 Madrid, Spain.; i+HeALTH, European University Miguel de Cervantes, 47012 Valladolid, Spain; Faculty of Sport Sciences, European University of Madrid, Villaviciosa de Odón, 28670 Madrid, Spain.

DOI: 10.1016/j.arr.2022.101640

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MeSH Terms: Aged, Biomarkers, Cognition, Healthy Aging, Humans