The effect of probiotics on gestational diabetes and its complications in pregnant mother and newborn: A systematic review and meta-analysis during 2010-2020.

Marzie Mahdizade Ari, Samane Teymouri, Tayebeh Fazlalian, Parisa Asadollahi, Roghayeh Afifirad, Mohammad Sabaghan, Fateme Valizadeh, Roya Ghanavati, Atieh Darbandi

Journal: Journal of clinical laboratory analysis 2022;36(4):e24326

PMID: 35243684

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Plain Language Summary

Gestational diabetes (GD) refers to glucose intolerance in pregnant women at 24–28 weeks without a history of diabetes that results in hyperglycaemia. Some studies suggest that probiotics are able to overcome insulin resistance in pregnant women with GD. The aim of this study was to investigate the inhibitory effects of probiotics supplementation on GD among pregnant women based on Randomized Controlled Trial studies during in the last 10 years (2010–2020). This study is a systematic review and meta-analysis of 28 studies. The age range of the pregnant women following the probiotics treatment was 18–40 years. Results show that taking probiotic supplements during pregnancy by women with GD has beneficial effects on the metabolic status, colostrum adiponectin levels, microbiome composition, and the maternal and infant health. However, 4 of the analysed studies did not find any significant effect for the probiotic intervention on the incidence of GD. Authors conclude that more homogeneous studies are needed to generalize the findings of this study. Thus, specific probiotic supplementation may be introduced as one of the adjuvant therapies for GD patients.

Abstract

This study was aimed to evaluate the effect of probiotics consumption on gestational diabetes (GD) and its complications in pregnant mother and newborn. The study was registered on PROSPERO (CRD42021243409) and all the enrolled articles were collected from four databases (Medline, Scopus, Embase, and Google Scholar) as randomized controlled trials (RCTs) from 2010 to 2020. A total of 4865 study participants from 28 selected studies were included in this review. The present meta-analysis showed that the consumption of probiotics supplementation has the potential to decrease GD-predisposing metabolic parameters such as blood glucose level, lipid profile, inflammation, and oxidative markers which may reduce GD occurrence among pregnant women.

Address: Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.; Microbial Biotechnology Research Centre, Iran University of Medical Sciences, Tehran, Iran.; Department of Microbial Biotechnology, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran.; Department of Microbiology, Faculty of medicine, Ilam University of Medical Sciences, Ilam, Iran.; Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.; Behbahan Faculty of Medical Sciences, Behbahan, Iran.; Department of Endodontics, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

DOI: 10.1002/jcla.24326