PKC regulation of ion channels: The involvement of PIP.

Kirin D Gada, Diomedes E Logothetis

Journal: The Journal of biological chemistry 2022;298(6):102035

PMID: 35588786

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Abstract

Ion channels are integral membrane proteins whose gating has been increasingly shown to depend on the presence of the low-abundance membrane phospholipid, phosphatidylinositol (4,5) bisphosphate. The expression and function of ion channels is tightly regulated via protein phosphorylation by specific kinases, including various PKC isoforms. Several channels have further been shown to be regulated by PKC through altered surface expression, probability of channel opening, shifts in voltage dependence of their activation, or changes in inactivation or desensitization. In this review, we survey the impact of phosphorylation of various ion channels by PKC isoforms and examine the dependence of phosphorylated ion channels on phosphatidylinositol (4,5) bisphosphate as a mechanistic endpoint to control channel gating.

Address: Department of Pharmaceutical Sciences, Bouvé College of Health Sciences and College of Science, Northeastern University, Boston, Massachusetts, USA.; Department of Pharmaceutical Sciences, Bouvé College of Health Sciences and College of Science, Northeastern University, Boston, Massachusetts, USA; Department of Chemistry and Chemical Biology, Bouvé College of Health Sciences and College of Science, Northeastern University, Boston, Massachusetts, USA; Center for Drug Discovery, Bouvé College of Health Sciences and College of Science, Northeastern University, Boston, Massachusetts, USA. Electronic address: [email protected].

DOI: 10.1016/j.jbc.2022.102035

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MeSH Terms: Ion Channels, Phosphatidylinositol 4,5-Diphosphate, Phosphorylation, Protein Kinase C