The LRRC8C-STING-p53 axis in T cells: A Ca affair.

Sonia Missiroli, Carlotta Giorgi, Paolo Pinton

Journal: Cell calcium 2022;105():102596

PMID: 35596964

Full Text on Elsevier Science View on PubMed

Abstract

Up to now, no role has been associated with VRAC channels in T cells. In a recent paper published in Nature Immunology, LRRC8C has been described as an essential component of VRAC in T cells. These data raise the intriguing possibility that the LRRC8C-STING-p53 signaling axis may represent a new inhibitory pathway in T cells that controls their function and adaptive immunity.

Address: Department of Medical Sciences, Section of Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.; Department of Medical Sciences, Section of Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy. Electronic address: [email protected].

DOI: 10.1016/j.ceca.2022.102596

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MeSH Terms: Membrane Proteins, Signal Transduction, T-Lymphocytes, Tumor Suppressor Protein p53