Xanthones from the stems of Calophyllum membranaceum Gardn. et Champ. and their anti-inflammatory activity.

Min Yu, Su-Juan Wang, Hua Li, Gui-Jie Zhang

Journal: Phytochemistry 2022;200():113246

PMID: 35605809

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Abstract

Eighteen undescribed xanthones, including six pairs of xanthone enantiomers, three xanthones, and three xanthone glycosides, together with one pair of known xanthone enantiomers and 12 known xanthones, were isolated from the stems of Calophyllum membranaceum Gardn. et Champ. Their structures were elucidated by spectroscopic analysis, and the absolute configuration of the enantiomers was determined by using experimental and calculated electronic circular dichroism data. All compounds were screened for their anti-inflammatory effects on LPS-induced BV-2 microglial cells. Among them, six compounds showed remarkable activities with IC values of 7.8-36.0 μM.

Address: College of Pharmacy, Guilin Medical University, Guilin, 541004, People's Republic of China.; College of Pharmacy, Guilin Medical University, Guilin, 541004, People's Republic of China. Electronic address: [email protected].

DOI: 10.1016/j.phytochem.2022.113246

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MeSH Terms: Anti-Inflammatory Agents, Calophyllum, Glycosides, Molecular Structure, Xanthones