Cardiovascular Disease and Possible Ways in Which Lycopene Acts as an Efficient Cardio-Protectant against Different Cardiovascular Risk Factors.

Ming-Ju Hsieh, Chih-Yang Huang, Rudolf Kiefer, Shin-Da Lee, Nancy Maurya, Bharath Kumar Velmurugan

Journal: Molecules (Basel, Switzerland) 2022;27(10):3235

PMID: 35630709

Abstract

Foods rich in antioxidants such as lycopene have a major role in maintaining cardiac health. Lycopene, 80% of which can be obtained by consuming a common vegetable such as tomato, can prevent the disturbances that contribute to cardiovascular disease (CVD). The present work begins with a brief introduction to CVD and lycopene and its various properties such as bioavailability, pharmacokinetics, etc. In this review, the potential cardio-protective effects of lycopene that reduce the progression of CVD and thrombotic complications are detailed. Further, the protective effects of lycopene including in vitro, in vivo and clinical trials conducted on lycopene for CVD protective effects are explained. Finally, the controversial aspect of lycopene as a protective agent against CVD and toxicity are also mentioned.

Address: Oral Cancer Research Center, Changhua Christian Hospital, Changhua 50006, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 40227, Taiwan.; School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.; Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung 41354, Taiwan.; Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.; Center of General Education, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien 970302, Taiwan.; Department of Medical Research, China Medical University Hospital, Taichung 40402, Taiwan.; Conducting Polymers in Composites and Applications Research Group, Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 758307, Vietnam.; Department of Physical Therapy, Asia University, Taichung 41354, Taiwan.; Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung 406040, Taiwan.; School of Rehabilitation Medicine, Weifang Medical University, Weifang 261053, China.; Botany Department, Government Science College, Pandhurna, Chhindwara, M.P., Pandhurna 480334, India.; Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 758307, Vietnam.

DOI: 10.3390/molecules27103235

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MeSH Terms: Antioxidants, Cardiovascular Diseases, Carotenoids, Heart Disease Risk Factors, Humans, Lycopene, Risk Factors