A Molecular Approach to Understanding the Role of Diet in Cancer-Related Fatigue: Challenges and Future Opportunities.

Sylvia L Crowder, Mary C Playdon, Lisa M Gudenkauf, Jennifer Ose, Biljana Gigic, Leigh Greathouse, Anita R Peoples, Alix G Sleight, Heather S L Jim, Jane C Figueiredo

Journal: Nutrients 2022;14(7):1496

PMID: 35406105

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Abstract

Cancer-related fatigue (CRF) is considered one of the most frequent and distressing symptoms for cancer survivors. Despite its high prevalence, factors that predispose, precipitate, and perpetuate CRF are poorly understood. Emerging research focuses on cancer and treatment-related nutritional complications, changes in body composition, and nutritional deficiencies that can compound CRF. Nutritional metabolomics, the novel study of diet-related metabolites in cells, tissues, and biofluids, offers a promising tool to further address these research gaps. In this position paper, we examine CRF risk factors, summarize metabolomics studies of CRF, outline dietary recommendations for the prevention and management of CRF in cancer survivorship, and identify knowledge gaps and challenges in applying nutritional metabolomics to understand dietary contributions to CRF over the cancer survivorship trajectory.

Address: Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL 33617, USA.; Cancer Control and Population Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA.; Department of Population Health Sciences, University of Utah, Salt Lake City, UT 84112, USA.; Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, 69047 Heidelberg, Germany.; Human Science and Design, Robbins College of Health and Human Sciences, Baylor University, Waco, TX 76798, USA.; Department of Physical Medicine and Rehabilitation, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Center for Integrated Research in Cancer and Lifestyle, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

DOI: 10.3390/nu14071496

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MeSH Terms: Cancer Survivors, Diet, Fatigue, Humans, Neoplasms, Prevalence