Nano-bio interactions of 2D molybdenum disulfide.

Shounak Roy, Kaivalya A Deo, Kanwar Abhay Singh, Hung Pang Lee, Amit Jaiswal, Akhilesh K Gaharwar

Journal: Advanced drug delivery reviews 2022;187():114361

PMID: 35636569

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Abstract

Two-dimensional (2D) molybdenum disulfide (MoS) is an ultrathin nanomaterial with a high degree of anisotropy, surface-to-volume ratio, chemical functionality and mechanical strength. These properties together enable MoS to emerge as a potent nanomaterial for diverse biomedical applications including drug delivery, regenerative medicine, biosensing and bioelectronics. Thus, understanding the interactions of MoS with its biological interface becomes indispensable. These interactions, referred to as "nano-bio" interactions, play a key role in determining the biocompatibility and the pathways through which the nanomaterial influences molecular, cellular and biological function. Herein, we provide a critical overview of the nano-bio interactions of MoS and emphasize on how these interactions dictate its biomedical applications including intracellular trafficking, biodistribution and biodegradation. Also, a critical evaluation of the interactions of MoS with proteins and specific cell types such as immune cells and progenitor/stem cells is illustrated which governs the short-term and long-term compatibility of MoS-based biomedical devices.

Address: Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX 77843, USA; School of Basic Sciences, Indian Institute of Technology - Mandi, Kamand, Mandi, Himachal Pradesh-175005, India.; Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX 77843, USA.; School of Basic Sciences, Indian Institute of Technology - Mandi, Kamand, Mandi, Himachal Pradesh-175005, India. Electronic address: [email protected].; Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX 77843, USA; Material Science and Engineering, College of Engineering, Texas A&M University, College Station, TX 77843, USA; Center for Remote Health Technologies and Systems, Texas A&M University, College Station, TX 77843, USA; Interdisciplinary Program in Genetics and Genomics, Texas A&M University, College Station, TX 77843, USA. Electronic address: [email protected].

DOI: 10.1016/j.addr.2022.114361

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MeSH Terms: Disulfides, Humans, Molybdenum, Nanostructures, Tissue Distribution