Highlighting the roles of transition metals and speciation in chemical biology.

Kateryna Kostenkova, Gonzalo Scalese, Dinorah Gambino, Debbie C Crans

Journal: Current opinion in chemical biology 2022;69():102155

PMID: 35643024

Full Text on Elsevier Science View on PubMed

Abstract

Transition metal ions play key structural and functional roles, affecting structures of biomolecules and enzyme function. The importance of transition metal ions in chemical biology is, thus, undisputed. However, the aqueous chemistry of metal ions is complicated because they form species in several protonation and redox states. In the presence of metabolites, metal ions can also form coordination complexes. The existence of several species is relevant because enzymes and membrane receptors can distinguish between species even when they are rapidly equilibrating. Thus, metal ions, enzyme cofactors, and therapeutic agents are sensitive to the metal ion speciation chemistry because it affects their interaction with enzymes and other biomolecules. Speciation is also crucial for metal-containing bioorthogonal reactions, since water and metabolites stabilize active catalysts, affect chemoselectivity and reaction yields.

Address: Department of Chemistry, Colorado State University, Fort Collins, CO, 80523, USA.; Department of Chemistry, Colorado State University, Fort Collins, CO, 80523, USA; Área Química Inorgánica, Facultad de Química, Universidad de la República, Montevideo, 11800, Uruguay.; Área Química Inorgánica, Facultad de Química, Universidad de la República, Montevideo, 11800, Uruguay. Electronic address: [email protected].; Department of Chemistry, Colorado State University, Fort Collins, CO, 80523, USA; Cell and Molecular Biology, Colorado State University, Fort Collins, CO, 80523, USA. Electronic address: [email protected].

DOI: 10.1016/j.cbpa.2022.102155

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MeSH Terms: Biology, Coordination Complexes, Ions, Metals, Transition Elements, Water