Shigella iron-binding proteins: An insight into molecular physiology, pathogenesis, and potential target vaccine development.

Che Muhammad Khairul Hisyam Bin Ismail, Nor Raihan Mohammad Shabani, Candy Chuah, Zurina Hassan, Abu Bakar Abdul Majeed, Chiuan Herng Leow, Kirnpal Kaur Banga Singh, Chiuan Yee Leow

Journal: Vaccine 2022;40(30):3991-3998

PMID: 35660036

Full Text on Elsevier Science View on PubMed

Abstract

Shigella is a well-known etiological agent responsible for intestinal infection among children, the elderly, and immunocompromised people ranging from mild to severe cases. Shigellosis remains endemic in Malaysia and yet there is no commercial vaccine available to eradicate the disease. Iron is an essential element for the survival of Shigella within the host. Hence, it is required for regulating metabolic mechanisms and virulence determinants. Alteration of iron status in the extracellular environment directly triggers the signal in enteropathogenic bacterial, providing information that they are in a hostile environment. To survive in an iron-limited environment, molecular regulation of iron-binding proteins plays a vital role in facilitating the transportation and utilization of sufficient iron sources. Given the importance of iron molecules for bacterial survival and pathogenicity, this review summarizes the physiological role of iron-binding proteins in bacterial survival and their potential use in vaccine and therapeutic developments.

Address: Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.; Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia; Faculty of Health Sciences, Universiti Teknologi MARA, Kampus Bertam, 13200 Kepala Batas, Penang, Malaysia.; Department of Medical and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia; Faculty of Health Sciences, Universiti Teknologi MARA, Kampus Bertam, 13200 Kepala Batas, Penang, Malaysia.; Centre for Drug Research, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.; Faculty of Pharmacy, Universiti Teknologi MARA, Kampus Puncak Alam, 42300 Kuala Selangor, Selangor, Malaysia.; Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.; Department of Medical and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.; School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia. Electronic address: [email protected].

DOI: 10.1016/j.vaccine.2022.05.061

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MeSH Terms: Aged, Bacterial Proteins, Child, Dysentery, Bacillary, Humans, Iron, Iron-Binding Proteins, Shigella, Vaccine Development