Centriole duplication: centrin in on answers?

Luke M Rice, David A Agard

Journal: Current biology : CB 2003;12(18):R618-9

PMID: 12372266

Free Full Text on Elsevier Science View on PubMed

Abstract

Many aspects of centriole biology remain mysterious. A new study has shed light on the role of the centriolar protein centrin-2: reducing levels of centrin-2 in HeLa cells has been found to block centriole duplication, eventually leading to cell death.

Address: Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA.

DOI: 10.1016/s0960-9822(02)01133-8

Link outs

Free resources

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0960...

MeSH Terms: Calcium-Binding Proteins, Cell Death, Cell Division, Centrioles, Chromosomal Proteins, Non-Histone, HeLa Cells, Humans, Models, Biological, RNA Interference