Synthesis, Processing and the Effect of Thermal Treatment on the Solubility, Antioxidant Potential and Cytocompatibility of Y2O3 and CeO2 doped SiO2-SrO-Na2O Glass-Ceramics.

Thermal treatment of a 0.52SiO-0.24SrO-0.24NaO-MO glass-ceramic series (where = 0.08 and MO = YO or CeO) was conducted in order to synthesize yttrium (Y) and cerium (Ce) crystalline species that may act as radical oxygen specie (ROS) scavengers. The prominent phase for the is a sodium-strontium-silicate while the experimental glass-ceramics (, , and present sodium-Y/Ce-silicate and oxide phases. Disk shrinkage during thermal processing ranges from 1-7% for , , , and in both diameter and thickness. Solubility studies determined that the release of Si and Na are greatest from the disks which peaks at 1550 µg/mL. Release from the Y and Ce glass-ceramics reached 320 µg/mL for Si and 630 µg/mL for Na. The range of antioxidant capacity (ABTS assay) for all samples was 0.31-3.9 mMTE. No significant reduction in MC 3T3 Osteoblast cell viability was observed for any composition tested.