A state-of-the-art review on fucoidan as an antiviral agent to combat viral infections.

Biswajita Pradhan, Rabindra Nayak, Srimanta Patra, Prajna Paramita Bhuyan, Pradyota Kumar Behera, Amiya Kumar Mandal, Chhandashree Behera, Jang-Seu Ki, Siba Prasad Adhikary, Davoodbasha MubarakAli, Mrutyunjay Jena

Journal: Carbohydrate polymers 2022;291():119551

PMID: 35698330

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Abstract

As a significant public health hazard with several drug side effects during medical treatment, searching for novel therapeutic natural medicines is promising. Sulfated polysaccharides from algae, such as fucoidan, have been discovered to have a variety of medical applications, including antibacterial and immunomodulatory properties. The review emphasized on the utilization of fucoidan as an antiviral agent against viral infections by inhibiting their attachment and replication. Moreover, it can also trigger immune response against viral infection in humans. This review suggested to be use the fucoidan for the potential protective remedy against COVID-19 and addressing the antiviral activities of sulfated polysaccharide, fucoidan derived from marine algae that could be used as an anti-COVID19 drug in near future.

Address: Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, Odisha, India; Department of Biotechnology, Sangmyung University, Seoul 03016, Republic of Korea.; Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, Odisha, India.; Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology Rourkela, Odisha, India.; Department of Botany, Maharaja Sriram Chandra Bhanja Deo University, Baripada 757003, Odisha, India.; Department of Chemistry, Berhampur University, Bhanja Bihar, Berhampur 760007, Odisha, India.; Department of Biotechnology, Sangmyung University, Seoul 03016, Republic of Korea.; Department of Biotechnology, Institute of Science, Visva-Bharati, Santiniketan 731235, West Bengal, India.; School of Life Sciences, B.S. Abdur Rahman Crescent Institute of Science and Technology, Chennai 600048, India. Electronic address: [email protected].; Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, Odisha, India. Electronic address: [email protected].

DOI: 10.1016/j.carbpol.2022.119551