The Dose-Response Effects of Consuming High Fructose Corn Syrup-Sweetened Beverages on Hepatic Lipid Content and Insulin Sensitivity in Young Adults.
Yasser Abdelhafez, Kimber L Stanhope, Peter J Havel, Abhijit J Chaudhari, Claude B Sirlin, Andrea Tura, Giovanni Pacini, Michael I Goran, Nancy L Keim, John P McGahan, Desiree M Sigala, Yanet Benyam, Candice A Price, Chad L Cox, Andrew A Bremer, Marinelle V Nunez, Vivien Lee, Valentina Medici, Bettina Hieronimus
Journal: Nutrients
2022;14(8):1648
PMID: 35458210
Abstract
["Increased hepatic lipid content and decreased insulin sensitivity have critical roles in the development of cardiometabolic diseases. Therefore, our objective was to investigate the dose-response effects of consuming high fructose corn syrup (HFCS)-sweetened beverages for two weeks on hepatic lipid content and insulin sensitivity in young (18-40 years) adults (BMI 18-35 kg\/m). In a parallel, double-blinded study, participants consumed three beverages\/day providing 0% (aspartame: = 23), 10% ( = 18), 17.5% ( = 16), or 25% ( = 28) daily energy requirements from HFCS. Magnetic resonance imaging for hepatic lipid content and oral glucose tolerance tests (OGTT) were conducted during 3.5-day inpatient visits at baseline and again at the end of a 15-day intervention. During the 12 intervening outpatient days participants consumed their usual diets with their assigned beverages. Significant linear dose-response effects were observed for increases of hepatic lipid content ( = 0.015) and glucose and insulin AUCs during OGTT (both = 0.0004), and for decreases in the Matsuda ( = 0.0087) and Predicted M ( = 0.0027) indices of insulin sensitivity. These dose-response effects strengthen the mechanistic evidence implicating consumption of HFCS-sweetened beverages as a contributor to the metabolic dysregulation that increases risk for nonalcoholic fatty liver disease and type 2 diabetes."]
Address:
Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, Sacramento, CA 95616, USA.; Department of Nutrition, University of California-Davis, Sacramento, CA 95616, USA.; Institute for Physiology and Biochemistry of Nutrition, Max Rubner-Institut, 76131 Karlsruhe, Germany.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of California-Davis, Sacramento, CA 95817, USA.; Department of Pediatrics, School of Medicine, University of California-Davis, Sacramento, CA 95817, USA.; Department of Chemistry, California State University, Sacramento, CA 95819, USA.; Department of Family and Consumer Sciences, California State University, Sacramento, CA 95819, USA.; Department of Radiology, School of Medicine, University of California-Davis, Sacramento, CA 95817, USA.; Western Human Nutrition Research Center, United States Department of Agriculture, Davis, CA 95616, USA.; The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.; Metabolic Unit, Institute of Neuroscience, National Research Council (CNR), 35127 Padova, Italy.; Liver Imaging Group, Department of Radiology, University of California-San Diego, La Jolla, CA 92093, USA.
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